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脂联素及受体、信号传导通路和相关疾病关系的研究进展(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2011年第3期
页码:
395-399
栏目:
综述
出版日期:
2011-05-12

文章信息/Info

Title:
-
作者:
刘雯雯1; 陈宁2综述; 殷仁富1审校
1.第二军医大学上海长征医院贵宾诊疗科28楼，2.第二军医大学上海长征医院消化科24楼，上海 200003
Author(s):
-
关键词:
脂联素; 脂联素受体; 信号传导
Keywords:
-
分类号:
R587.1
DOI:
-
文献标识码:
A
摘要:
最早在白色脂肪细胞中发脂联素（APN）及其受体(AdipoR)，现表明APN、 AdipoR也在心肌细胞、骨骼肌细胞、成骨细胞、肾脏足细胞及胎盘、唾液腺上皮、脑垂体等组织中表达。APN与 AdipoR结合后通过相应的信号传导途径发挥作用。APN、AdipoR水平下降或其信号传导途径中某一环节出现差错均可能导致胰岛素抵抗、糖尿病、动脉粥样硬化、代谢综合征发生，还可引起营养不良、肝纤维化、心肌梗死后心肌重构、自体骨质破坏、眼-肾-脑综合征疾病。
Abstract:
-

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备注/Memo

备注/Memo:
收稿日期：2010-04-07.通讯作者：殷仁富，主任医师，主要从事心脏能量代谢与治疗的研究 Email：yinrenfu28@sohu.com 作者简介：刘雯雯，硕士生Email：wl_med@yahoo.cn
更新日期/Last Update: 2011-03-17