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|本期目录/Table of Contents|

FoxO3a转录因子与心血管疾病的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第2期
页码:
222-224232
栏目:
综述
出版日期:
2014-01-20

文章信息/Info

Title:
Research progress in FoxO3a and cardiovascular disease
作者:
郑星星; 王建刚
(中南大学湘雅三医院心血管内科,湖南 长沙 410013)
Author(s):
ZHENG Xing-xing;  WANG Jian-gang
(Department of Cardiology, Third Xiang-ya Hospital, Central South University, Changsha 410013, Hunan, China)
关键词:
转录因子; FoxO3a; 心血管疾病
Keywords:
transcription factor;  FoxO3a;  cardiovascular disease
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
FoxO3a是Forkhead家族的一个重要成员。随着对FoxO3a在肿瘤进程中异常表达的研究不断深入，发现其可调节血管平滑肌、内皮细胞及心肌细胞在多种病理生理因素作用下的生物学特性改变，在抗氧化应激中也具有重要作用。FoxO3a与心血管疾病及其危险因素相关，现就其在心血管疾病中的作用研究进展作一综述。
Abstract:
Forkhead Fox O (FoxO) 3a, one of the FoxO family members, has been shown to be deregulated in many types of human cancers. Recent studies have shown that in addition to its activity to enhance vascular antioxidant properties, FoxO3a also appears to be necessary in modulating vascular smooth muscle proliferation, endothelial cell development and cardiomyocyte growth in pathological or biological processes. In this article we review the research progress in FoxO3a and cardiovascular disease.

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备注/Memo

备注/Memo:
收稿日期：2013-07-14.
通讯作者：王建刚，副教授，主要从事高血压、冠心病研究 Email：wang0410@xy3yy.com
作者简介：郑星星，硕士生Email：zhengxingxing_258@163.com
更新日期/Last Update: 2014-01-16