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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2016年第2期

页码:

149-152

栏目:

基础研究

出版日期:

2015-11-25

文章信息/Info

Title:

Effect of electrical stimulation of aortic root ventricular ganglionated plexi on autonomic nervous system-mediated atrial fibrillation

作者:

范博渊¹; 何宜轩²; 王 彬¹; 艾永飞¹; 马文帅¹; 赵楠楠¹; 王洪涛¹

(第四军医大学:1.唐都医院心脏内科，陕西 西安 710038,2.学员旅二营五连，陕西 西安 710032）

Author(s):

FAN Bo-yuan¹;  HE Yi-xuan²;  WANG Bin¹;  AI Yong-fen¹;  MA Wen-shuai¹;  ZHAO Nan-nan¹;  WANG Hong-tao¹

(1.Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi, China, 2.Cadet Brigade, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)

关键词:

心室主动脉根部神经节丛; 自主神经系统; 肺静脉; 房颤

Keywords:

aortic root ventricular ganglionated plexi;  autonomic nervous system;  pulmonary vein;  atrial fibrillation

分类号:

R541.75

DOI:

-

文献标识码:

A

摘要:

目的 本研究探讨低频电刺激心室主动脉根部神经节丛（ganglionated plexi,GP）对肺静脉源性房颤(AF)诱发率的影响。方法 20只犬分别测量基础状态下，高频和低频电刺激主动脉根部GP时的心房有效不应期和肺静脉有效不应期。分别在基础状态下，高频和低频电刺激主动脉根部GP时，自肺静脉远端以程序刺激诱发AF和AF诱发率的变化。结果 高频电刺激主动脉根部GP 明显缩短心房的肺静脉的有效不应期，增加AF的诱发率。而低频电刺激使心房及肺静脉有效不应期呈延长趋势，并降低AF诱发率。结论 低频电刺激主动脉根部GP降低自主神经介导的AF诱发率。

Abstract:

AIM To investigate the effect of electrical stimulation of aortic root ventricular ganglionated plexi (GP) on autonomic nervous system-mediated atrial fibrillation (AF) inducibility. METHODS Effective refractory periods (ERP) of the atria and the pulmonary vein (PV) were measured at baseline, high-level (HL-ES) and low-level (LL-ES) electrical stimulation of aortic root ventricular GP. AF was induced at distal PV by programmed stimulation to measure AF inducibility at baseline, HL-ES or LL-ES. RESULTS HL-ES of aortic root GP significantly shortened ERP of the atria and ERP of the PVs and increased the AF-inducing rate arising from PVs. However, LL-ES of this GP prevented the shortening of ERP and decreased AF inducing rate. CONCLUSION LL-ES of aortic root ventricular GP decreases AF inducibility arising from PVs mediated by the autonomic nervous system.

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备注/Memo

备注/Memo:

收稿日期：2015-01-19.
基金项目：陕西省自然科学基金项目资助（2015JM8461）
通讯作者：王洪涛，主治医师，主要从事心律失常和心房颤动研究 Email：287561457@qq.com
作者简介：范博渊，住院医师，硕士 Email：277399335@qq.com
共同第一作者：何宜轩，本科生 Email：12558828376@qq.com

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更新日期/Last Update: 2016-04-25