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|本期目录/Table of Contents|

microRNAs在心血管生物学及心血管疾病中的研究进展

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第5期
页码:
595-600
栏目:
综述
出版日期:
2017-03-25

文章信息/Info

Title:
Research progress of microRNAs in cardiovascular biology and cardiovascular diseases
作者:
杜建奎1; 朱晓燕1; 闾坚强2; 倪 鑫1
(1.第二军医大学生理学教研室，上海 200433；
2.上海体育学院运动科学学院，上海 200438)
Author(s):
DU Jian-kui1;  ZHU Xiao-yan1;  LV Jian-qiang2;  NI Xin1
(1.Department of Physiology, Second Military Medical University, Shanghai 200433, China；
2.School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China)
关键词:
microRNAs; 心血管疾病; 心肌重构; 缺血性心脏病; 心律不齐
Keywords:
microRNAs;  cardiovascular disease;  cardiac remodeling;  ischemic heart disease;  arrhythmia
分类号:
R54
DOI:
-
文献标识码:
A
摘要:
心血管疾病是导致人类死亡的主要原因之一，心血管疾病所引起人类死亡约占全球死亡总数的30%。microRNAs（miRNAs）是一类通过调节靶mRNA转录或转录后翻译诱导靶基因表达沉默而发挥广泛生物学作用的非编码RNA。近年来，大量研究表明：miRNAs在哺乳动物心血管系统中广泛表达并在多种心血管疾病的病理发生过程中发挥着关键的调节作用，包括心脏重构、缺血性心脏疾病以及心律不齐等。miRNAs在心血管疾病中如此广泛的作用为阐明心血管疾病的发病机制提供了新的视角并为心血管疾病的诊断与治疗提供了新的靶点。
Abstract:
Cardiovascular disease is one of the major causes of morbidity and mortality worldwide. Human deaths caused by cardiovascular disease account for about 30% of all deaths worldwide. MicroRNAs (miRNAs) are a class of non-coding RNAs which exert a wide range of biological effects through regulating the transcription of target mRNA or inducing silence of target genes at the post transcriptional level. Recently, a number of researches indicate that miRNAs are ubiquitously expressed in mammalian cardiovascular system and play critical roles in a variety of pathological processes of cardiovascular diseases, including cardiac remodeling, ischemic heart disease and arrhythmia. The wide roles of miRNAs in cardiovascular diseases provide new sights into illuminating the pathogenesis and novel targets for the diagnosis and treatment of cardiovascular diseases.

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备注/Memo

备注/Memo:
收稿日期: 2016-03-24.
基金项目：国家自然科学基金项目资助（31571227）
通讯作者：倪鑫，教授，主要从事生殖内分泌与心血管生理研究 Email：nixin@smmu.edu.cn
作者简介：杜建奎，博士生 Email：dujiankuismmu@126.com
更新日期/Last Update: 2017-04-20