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异丙肾上腺素对异氟醚犬心血管效应的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第6期
页码:
461-463，466
栏目:
论著
出版日期:
2001-11-01

文章信息/Info

Title:
Influence of isoprenaline on the cardiovascular effects caused by isoflurane in Dogs
作者:
侯立朝1;  张　宏2;  熊利泽1;  张高魁3;  靳　冰2
1. 第四军医大学西京医院麻醉科, 陕西西安710033; 解放军总医院: 2. 麻醉科, 3. 统计学教研室, 北京100853
Author(s):
HOU Li-chao1;  ZHANG Hong2;  XIONG Li-ze1;  ZHANG Gao-kui3;  JIN Bing2
1. Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an Shaanxi 710033, China; 2. Department of Anesthesiology, 3. Department of Statistics, General Hospital of PLA. Beijing 100853, China
关键词:
异丙肾上腺素;  异氟醚;  心血管系统
Keywords:
Isoprenaline;  Isoflurane;  Cardiovascular system
分类号:
R971. 2
DOI:
-
文献标识码:
A
摘要:
目的 探讨异丙肾上腺素(ISP) 对异氟醚的心血管效应的影响。方法 本实验分为异氟醚低浓度[0. 85% , 0. 6MAC (最小肺泡有效浓度)]和高浓度(1. 70% , 1. 2MAC) 两部分。每部分实验选择32 只健康杂种犬, 随机分为4 组 (每组8 例): 对照组, 异氟醚组, ISP 组和ISP+ 异氟醚组。监测有创动脉血压、肺动脉压、肺动脉楔嵌压、中心静脉压、心排出量和心率。记录上述参数在用药20 min 后的变化。结果 在硫喷妥钠麻醉犬上静脉滴注0. 02 Lg.kg- 1.min- 1的ISP 和0. 6MAC 及1. 2MAC 异氟醚的心血管效应之间均没有交互作用。结论 ISP 对临床浓度的异氟醚的心血管效应没有显著影响。
Abstract:
AIM To explore the influence of isoprenaline on cardiovascular effects caused by isoflurane. METHODS This study included two parts: low-concent ration isoflurane (0. 85vol% ,0. 6MAC) and high-concent ration isoflurane (1. 70vo l% , 1. 2MAC). 32 healthy dogs in either part of experiments were randomly divided into four groups (n= 8 for each group ) : Isoflurane+isop renaline group , Isoprenaline group , Isoflurane group , and Control group. Invasive arterial blood pressure, pulmonary arterial pressure, pulmonary arterial wedge pressure, central venous pressure, cardiac output as well as heart rate were monitored in all dogs. RESULTS In thiopental-anesthetized dogs, no in teraction existed between the cardiovascular effects caused by isoflurane in either 0. 85vol% (0. 6 MAC) or 1. 70vol% (1. 2 MAC) and the cardiovascular effects caused by in travenousisop renaline at the rate of 0. 02 Lg.kg- 1.min- 1. CONCLUSION Isoprenaline had no significant influence on the cardiovascular effects caused by isoflurane in dogs.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2000-12-26.
更新日期/Last Update: 2001-11-01