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冠脑益嗪对大鼠心肌缺血/再灌注损伤保护作用的机制(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第1期
页码:
4-6
栏目:
论著
出版日期:
2002-01-01

文章信息/Info

Title:
Protective effect of corocinnarine on ischemia-reperfusion myocardium of rats and its relation to anti-lipid peroxidation
作者:
郭　群1; 陈水英2; 姚秀娟2; 张作明1
第四军医大学: 1.航空航天医学系航空临床医学教研室。2.药理学教研室, 陕西 西安 710032
Author(s):
GUO Qun;  CHEN Shui-ying ;  YAO Xiu-juan;  ZHANG Zuo-ming
Fourth Military Medical University, Xi’an, Shaanxi 710032, China
关键词:
心肌再灌注损伤;  冠脑益嗪;  超氧化物歧化酶;  丙二醛;  钙;  心律失常
Keywords:
corocinnarine;  myocardial reperfusion injury;  arrhythmia;  creatine kinase;  lactate dehydeogenase;  calcium;  lipid peroxidation
分类号:
R972
DOI:
-
文献标识码:
A
摘要:
目的 观察冠脑益嗪对大鼠心肌缺血/再灌注损伤的影响, 探讨其保护作用的机制。方法 采用在体大鼠心肌缺血/再灌注模型, 于结扎冠状动脉前3min iv 冠脑益嗪, 观察在心肌缺血/再灌注状态下心电图、心肌丙二醛(MDA )、超氧化物歧化酶(SOD)、Ca2+ 、游离脂肪酸(FFA ) 及血清中肌酸激酶(CK)、乳酸脱氢酶(LDH) 的变化。结果 冠脑益嗪能显著降低缺血/再灌注损伤引起的室性心律失常发生率, 缩短持续时间; 升高SOD 活性, 减少MDA生成; 减少Ca2+ 在心肌组织内的聚积; 亦能明显降低心肌CK、LDH 和FFA 的释放。结论 冠脑益嗪对大鼠心肌缺血/再灌注损伤的保护作用可能与保护氧自由基清除酶的活性, 防止膜脂质过氧化及阻断钙内流有关。
Abstract:
AIM To study the protective effect of corocinnarine (Cor) on ischemia-reperfusion myocardium. METHODS The myocardial ischemia-reperfusion model of rats in vivo was applied to the present study. Cor (5. 0 m g.kg- 1)was in jected in travenously 3 min before the ligation of coronary artery. ECGs of rats under ischema-reperfusion condition were recorded. The contents of myocardial m alondialdehyde (MDA ), superoxide dismutase(SOD ), calcium , myocardial creatine kinase (CK) and lactate dehydrogenase (LDH ) inserum were measured. RESULTS Pretreatment with Cor could significantly decrease the incidence and duration of ventricular arrhythmias induced by myocardial ischemia-reperfusion, reduce the release of myocrdial CK and LDH, lower the calcium accumulation in myocardium , decrease the generation of MDA and improve the activity of SOD. CONCLUSION Cor has a significant protective effect on myocardial ischemia-reperfusion injury and the protective effect might associate with its effects of improving SOD activity and prohibiting lipid peroxidation.

参考文献/References

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[2] 陈水英, 赵德化, 盛宝恒. 冠脑益嗪抗实验性心律失常的作用[J]. 第四军医大学学报,1987,8(4):235.

[3] 胡萍, 尤家马录, 罗正曜. 大白鼠心脏再灌流综合征模型[J]. 湖南医学院学报,1986,11(1):15-17.

[4] Makotoks O. Lipid peroxidation measurement[J].Saishinigaku,1978,33(3):660-664.

[5] Kono Y. Generation of superoxide radical during autooxidation of hydroxylamine and assay for superoxide dismutase[J]. Arch Biochem Biophys, 1978,186(1):189-195.

[6] 罗晓波, 刘立英, 陈修. 钙、氧自由基、前列腺素及其类似物与心肌缺血/再灌注损伤[J]. 中国药理学通报,1992,8:174.

[7] Richard EC. Lgnacio YC. John CV , et al. Use of nifedipine to decrease ischemic-reperfusion injury in the surgical setting [J].Am J Cardial, 1985,55:125B- 138B.

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备注/Memo

备注/Memo:
收稿日期：2001-04-30.
更新日期/Last Update: 2002-01-01