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比索洛尔对心力衰竭患者心功能及血淋巴细胞内游离钙浓度的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第1期
页码:
16-18
栏目:
论著
出版日期:
2002-01-01

文章信息/Info

Title:
The effect of Bisoprolol treatment on heart function and introlymphocytic free calcium concentration in congestive heart failure
作者:
何建新;  易绍东;  邱　建
广州军区广州总医院心血管内科, 广东 广州 510010
Author(s):
HE Jian-xin;  YI Shao-dong ; QIU Jian
Department of Cardiology, General Hospital of Guangzhou PLA , Guangzhou Guangdong 510010,China
关键词:
心力衰竭;  充血性;  比索洛尔;  钙超载
Keywords:
heart failure;  congestive; Bisoprolol;  calcium overload
分类号:
R541.61; R972
DOI:
-
文献标识码:
A
摘要:
目的 研究心力衰竭患者心功能与血淋巴细胞内游离钙浓度的关系及比索洛尔对二者的影响。方法 应用超声心动图及荧光分光光度计分别测定40例心力衰竭患者和15例健康人的左室舒缩功能和血淋巴细胞内游离钙浓度([Ca2+]i) ,心衰患者中25例在强心、利尿、扩血管等治疗基础上加用比索洛尔5mg/d , 另15例患者仅常规治疗。3周后重复各项检查。结果 ①心衰患者血淋巴细胞内[Ca2+]i显著高于正常对照组。②比索洛尔治疗3周后,心功能改善, 血淋巴细胞内[Ca2+]i 明显降低(P<0.01)。③心功能改善程度与[Ca2+]i 降幅呈正相关( r=0.68, P<0.01)。结论 比索洛尔与心力衰竭常规治疗联合应用, 能明显改善患者心功能, 其机制可能与抑制交感神经过亢活性, 逆转心肌细胞内Ca2+超载有关。
Abstract:
AIM To study the correlation between heart function and in trolymphocytic free calcium concent ration and the effect of Bisoprolol on them in congestive heart failure (CHF).METHODS Forty patients with CHF were given conventional treatments. Among them , twenty five cases also took Bisoprolo l5 mg per day. The heart function were measured by echocardiography in all patients, simultaneously, the concent ration of intralymphacytic free calcium([Ca2+]i) was measured by fluoresence spectrophotometer before and after three weeks treatment. As a contrast, fifteen normal individuals were examined. RESULTS ①Compared with normal control group,patients with CHF had higher [Ca2+]i. ②After three weeks Bisoprolol administration, there were significant improvements in heart function and marked decrease in [Ca2+]i. ③The improvements in heart function were positively related to the decrease in [Ca2+]i.CONCLUSION Bisoprolol can improve the heart function of the patients with CHF, the mechanism may be partly due to the inhibition of the increased sympathetic activity and reversion of the intracellular calcium overload in patients with CHF.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2000-09-28.
更新日期/Last Update: 2002-01-01