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心脏肌钙蛋白I对急性心肌梗死患者心功能预后的判断价值(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第4期
页码:
331-332,335
栏目:
临床研究
出版日期:
2003-07-01

文章信息/Info

Title:
Predictable value of serum cardiac troponin I in acute myocardial infarction with left vetricular function and prognosis
作者:
姜昌浩; 叶国良; 陈雯艾; 朱胜英; 周雪英; 陈智理; 宣云岗; 骆高江; 宗金波
义乌市人民医院心内科,浙江 义乌 322000
Author(s):
JIANG Chang-hao;  YE Guo-liang;  CHEN Wen-ai;  ZHU Sheng-ying;  ZHOU Xue-ying;  CHEN Zhi-li;  XUAN Yun-gang;  LUO Gao-jiang;  ZONG Jin-bo
Department of Cardiology, Yiwu People's Hospital, Yiwu, Zhejiang 322000, China
关键词:
心脏肌钙蛋白 I; 心肌梗塞; 急性; 溶栓; 心室功能; 左
Keywords:
cardiactroponin I;  acute myocardial infarction;  thrombolysis;  ventricular funtion;  left
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的:探讨心脏肌钙蛋白I(cTnI)对急性心肌梗死(AMI)患者心功能预后的判断价值。方法:AMI患者34例(溶栓再通组18例,未溶栓组16例),每例患者采用序列采血测定血清cTnI,并检测1月末左心室射血分数(LVEF)。结果:AMI患者血清的ΣcTnI与1月末LVEF呈负相关(P<0.05)。溶栓再通患者的cTnI峰值浓度与 1月末LVEF进行相关分析,有明显的负相关(P<0.05),未溶栓患者的cTnI峰值浓度与1月末LVEF无明显相关(P>0.05),溶栓再通患者cTnI峰值浓度明显高于未溶栓患者(P<0.01)。结论:AMI患者的ΣcTnI和溶栓再通患者的峰值浓度均可作为判断左心功能的预后指标。
Abstract:
AIM: To explore the predictable value of serum cardiac troponin I (cTn I) in acute myocardial infarction (AMI) patients with left vetricular function and prognosis. METHODS: The patient population consisted of 34 AMI patients (18 receiving reperfusion after venous thrombolysis and 16 non-thrombolysis). Blood samples were collected serially in AMI patients, and the left vetricular functionand prognosis were checked at the end of month. RESULTS: Serum cumulative cTn I concentraton (ΣcTn I) showed negative correlation with LVEF at the endofone month; Serum cTn I peak value in patient with reperfusion after thrombolysis showed significantly negative correlation with LVEF at the endofone month (r=-0.496,P<0.05); serum cTn I peak value in patient with no thrombolysis showed no correlation with LVEF at the endofone month (P> 0.05). Serum cTn I peak value in patient with reperfusion after thrombolysis were higher than no thrombolysis (P<0.01). CONCLUSION: Σ cTn I of AMI patients and the peak of cTn I in reperfusion patients is a reference index fo restimating left vetricular function and prognosis.

参考文献/References

[1] Cummins P, Young A, Auckland ML, et al. Comparison of serum cardiac specific troponin I with creatine kinase, creatine kinase-MB isoenzyme, tropomysion, myoglobin and C-reactive protein release in marathon runners: Cardiac or skeletal muscle trauma [J] . Eur J Clin Invest, 1987, 17(6):317-322.

[2] 姜昌浩, 叶国良, 洪小飞. 心脏肌钙蛋白I诊断急性心肌梗死的价值 [J] . 心脏杂志, 2000, 12(3):177-178.

[3] 陈在嘉, 寇文容, 徐义枢. 急性心肌梗塞尿激酶临床应用研究(1138例) [J] . 中华心血管病杂志, 1996, 24(3):169-172.

[4] Adams JE, Schechtman KB, Landt Y, et al. Comparable detection of acute myocardial infarction by CK-MB and cTn I [J] . Clin Chem, 1994, 40:1291-1295.

[5] Cummins B, Auckland M, Cummins P. Cardiac-specific troponin I, radioimmunossay in the diagnosis of acute myocardial infarction [J] . Am Heart J, 1987, 113(6):1333-1337.

[6] 李静, 胡大一, 项志敏, 等. 血清心脏肌钙蛋白I在急性心肌梗塞中的临床价值 [J] . 中国循环杂志, 1999, 14(增刊):42-45.

备注/Memo

备注/Memo:
收稿日期：2002-06-10.
更新日期/Last Update: 2003-07-01