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|本期目录/Table of Contents|

甲状腺功能亢进与心室复极化关系的meta分析

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2014年第3期
页码:
301-305
栏目:
临床研究
出版日期:
2014-03-20

文章信息/Info

Title:
A meta-analysis of the relationship between hyperthyroidism and ventricular repolarization
作者:
刘国才; 周 洁; 高 彬; 孙 飞; 张妙娟; 姬秋和
(第四军医大学西京医院内分泌代谢科，陕西 西安 710032)
Author(s):
LIU Guo cai;  ZHOU Jie;  GAO Bin;  SUN Fei;  ZHANG Miao juan;  JI Qiu he
(Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China)
关键词:
甲状腺功能亢进; 心室复极化; QT间期; QT离散度; Meta分析
Keywords:
hyperthyroidism;  ventricular repolarization;  QT interval;  QT dispersion;  meta-analysis
分类号:
R581.1
DOI:
-
文献标识码:
A
摘要:
目的:分析甲状腺功能亢进（甲亢）对于心室复极化的影响。方法:计算机检索PubMed、EMBASE、中国期刊全文数据库、维普数据库、万方数据库于1960年~2013年12月公开发表的相关文献，用Revman 5.2进行meta分析。结果:分析纳入7项病例对照研究，甲亢病例425例，对照组366例。甲亢时心率校正的QT间期（QTc)较对照组显著延长（MD=18.46,95%CI：10.19-26.73,P<0.01），心率校正的QT离散度(QTcd)也显著延长（MD=19.38, 95%CI：13.59-25.18,P<0.01）。QT间期与对数化后的促甲状腺素（TSH）呈负相关(Pearson相关系数r=-0.748，P<0.01；加权线性回归系数R2=0.557，P<0.01)。结论:甲亢患者的心室复极化显著延长。
Abstract:
AIM:To determine whether hyperthyroidism has an effect on ventricular repolarization. METHODS: PUBMED, EMBASE, China National Knowledge Internet (CNKI), VIP-database and Wanfang Database were searched. Case-control studies focusing on hyperthyroidism and ventricular repolarization published between 1960 and 2013 were collected. RevMan 5.2 was used to perform the meta-analysis. RESULTS: The meta-analysis included seven case-control studies and a total of 425 hyperthyroid patients and 366 healthy controls were included. Compared with controls, hyperthyroid patients showed a prolonged QT interval (MD=18.46, 95%CI=10.19 to 26.73), P<0.01) and a prolonged QT interval dispersion (MD=19.38, 95%CI=13.59 to 25.18, P<0.01). Moreover, QTc was negatively correlated with the logarithm of TSH levels (Pearson correlation coefficient r=-0.748, P<0.01; weighted linear regression coefficient R2=0.557). CONCLUSION: Hyperthyroidism is associated with ventricular repolarization prolongation.

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备注/Memo

备注/Memo:
收稿日期：2014-01-06.
通讯作者：姬秋和，主任医师，主要从事糖尿病、甲状腺疾病研究 Email:jqiuhe@fmmu.edu.cn
作者简介：刘国才，博士生 Email:duguhuanmeng@163.com
更新日期/Last Update: 2014-03-21