我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

厄贝沙坦对中老年男性高血压病患者骨质代谢的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2017年第3期
页码:
322-324,328
栏目:
临床研究
出版日期:
2017-01-25

文章信息/Info

Title:
Effect of irbesartan on skeletal metabolism in moderately elderly males with primary hypertension
作者:
常 华1; 2; 3; 李 琳3; 孟兆同3; 衣桂燕1; 赫 平4; 和渝斌1
解放军陆军总医院：1.心血管内科，4.骨科中心，北京 100700；2.第四军医大学西京医院心血管内科，陕西 西安 710032；3.96669部队门诊部，北京 102208
Author(s):
CHANG Hua1; 2; 3;  LI Lin3;  MENG Zhao-tong3;  YI Gui-yan1;  HE Ping4;  HE Yu-bin1
1.Department of Cardiology, 4.Department of Orthopaedics, PLA Army General Hospital, Beijing 100700, China; 2.Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi, China; 3.Outpatient Department, Unit 96669,
关键词:
厄贝沙坦; 骨密度; 骨折; 中老年男性; 高血压; 原发性
Keywords:
irbesartan;  bone mineral density;  fracture;  moderately elderly males;  primary hypertension
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨厄贝沙坦对中老年男性原发性高血压（primary hypertension，PH）患者骨质代谢的影响。方法 回顾性分析，随机选择年龄在40~89岁的中老年男性PH患者94例。按服用治疗高血压药物的类别分为2组：厄贝沙坦治疗组（34例，长期服用治疗剂量厄贝沙坦）和对照组〔60例，服用非血管紧张素转换酶抑制剂（ACEI）/血管紧张素Ⅱ受体阻滞剂（ARB）类药物〕。分别比较2组血清钙、磷浓度、碱性磷酸酶（alkaline phosphatase，ALP）浓度、骨密度（bone mineral density，BMD）、骨折发生率的差异。结果 厄贝沙坦治疗组患者股骨颈部、股骨总和、腰椎部位BMD和BMD与正常成人峰值比较积分（T值）相较于非ACEI/ARB类药物治疗组显著增加。结论 厄贝沙坦对于中老年男性PH患者具有一定的骨保护作用。
Abstract:
AIM To observe the effect of irbesartan on skeletal metabolism in moderately elderly males with primary hypertension (PH). METHODS Ninety-four male PH patients aged from 40-89 years were enrolled and divided into irbesartan group (therapeutic dose, >3 years, n=34) and contral no treatment group (no ACEI/ARB treatment, n=60). The difference of bone mineral density (BMD), fracture ratio, concentration of serum calcium, phosphorus and alkaline phosphatase was compared between groups. RESULTS Compared with those in the no ACEI/ARB treatment group, T value and BMD of femoral neck, total femur and vertebra lumbalis increased significantly in irbesartan group. CONCLUSION Irbesartan exerts protective effects on the skeletal system in moderately elderly males with PH.

参考文献/References

[1]何 真.老年原发性高血压骨密度变化分析[J].中国误诊学杂志,2008,8(25):6092-6039.
[2]Yang S,Nguyen ND,Center JR,et al.Association between hypertension and fragility fracture:a longitudinal study[J].Osteoporos Int,2014,25(1):97-103.
[3]Butt DA,Alharty R,Leu R,et al.Hypertension,Antihypertensive Drugs and the Risk of Fractures[J].Clinic Rev Bone Miner Metab,2015,13(3):160-172.
[4]Park JS,Choi SB,Rhee Y,et al.Parathyroid Hormone,Calcium, and Sodium Bridging Between Osteoporosis and Hypertension in Postmenopausal Korean Women[J].Calcif Tissue Int,2015,96(5):417-429.
[5]Masugata H,Senda S,lnukai M,et al.Association between bone mineraI desity and arterial stiffness in hypertensive patients[J].Tohoku J Exp Med,2011,223(2):85-90.
[6]Ghosh M,Majumdar SR.Antihypertensive medications,bone mineral density,and fractures: a review of old cardiac drugs that provides new insights into osteoporosis[J].Endocrine,2014,46(3):397-405.
[7]和渝斌,何冰娟,宋迎新,等.美托洛尔对老年男性原发性高血压患者骨代谢的影响[J].中华高血压杂志,2009,17(6):520-523.
[8]朱明玉.厄贝沙坦联合美托洛尔治疗高血压心脏病的临床效果及安全性观察[J].中国社区医师,2015,31(3):19-20.
[9]林 涛，耿 睿.厄贝沙坦联合苯磺酸氨氯地平治疗糖尿病合并高血压的临床研究[J].中国卫生标准管理,2015,6(4):106-107.
[10]焦林娟.厄贝沙坦治疗糖尿病肾病临床疗效及对患者肾保护作用研究[J].中国医药科学,2015,5(23):212-214.
[11]张 英.硝苯地平联合厄贝沙坦治疗2型糖尿病合并高血压的临床疗效与安全性观察[J].中国医药指,2016,14(6):48-49.
[12]Asaba Y,Ito M,Fumoto T,et al.Activation of renin-angiotensin system induces osteoporosis independently of hypertension[J].J Bone Miner Res,2009,24(2):241-250.
[13]Rajkumar DSR,Faitelson AV,Gudyrev OS,et al.Comparative evaluation of enalapril and losartan in pharmacological correction of experimental osteoporosis and fractures of its background[J].J Osteoporos,2013, 2013:325693.
[14]Donmez BO,Ozdemir S,Sarikanat M,et al.Effect of angiotensin II type 1 receptor blocker on osteoporotic rat femurs[J].Pharmacol Rep,2012,64(4):878-888.
[15]Kang KY,Kang Y,Kim M,et al.The effects of antihypertensive drugs on bone mineral density in ovariectomized mice[J].J Korean Med Sci,2013,28(8):1139-1144.
[16]Aoki M,Kawahata H,Sotobayashi D,et al.Effect of angiotensin II receptor blocker,olmesartan, on turnover of bone metabolism in bedridden elderly hypertensive women with disuse syndrome[J].Geriatr Gerontol Int,2015,15(8):1064-1072.
[17]李霞绯,吴 娟.依那普利和替米沙坦对绝经后原发性高血压女性患者骨密度及骨转化的影响[J].中国药房,2013,24(48):4534-4536.

备注/Memo

备注/Memo:
收稿日期：2016-06-28.通讯作者：和渝斌，主任医师，主要从事高血压病和脂代谢异常等疾病诊治研究 Email:yuhe603@yahoo.com 作者简介：常华，住院医师，硕士生 Email：240800479@qq.com
更新日期/Last Update: 2017-02-20